DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …

Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53
mutations, present at advanced stage, and eventually become resistant to chemotherapy …

We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in>
80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K …

Although endometrial cancer management remains challenging, a deeper understanding of
the genetic diversity as well as the drivers of the various pathogenic states of this disease …

Recent evidence suggests that ovarian high‐grade serous carcinoma (HGSC) originates
from the epithelium of the fallopian tube. However, most mouse models are based on the …

The distal Fallopian tube is a site of origin for many 'ovarian'high‐grade serous carcinomas
(HGSCs) with intraepithelial carcinomas (STICs) that share identical TP53 mutations with …

Serous tubal intraepithelial carcinoma (STIC) has been implicated in the pathogenesis of
pelvic serous carcinoma. We hypothesized that, if this is the case, the frequency of STIC …

The distinction between uterine serous and endometrioid carcinomas can usually be
achieved by morphologic examination alone. However, there are occasional …

Endometrial carcinoma is the most common invasive neoplasm of the female genital tract
and the fourth most frequently diagnosed cancer in women in the USA. In 2008, it is …

Beginning with the discovery of the BRCA-associated ovarian cancer susceptibility genes
and subsequent detailed examination of risk-reducing salpingo-oophorectomy (RRSO) …