Vitamin B12 is assimilated and transported by complex mechanisms that involve three
transport proteins, intrinsic factor (IF), haptocorrin (HC) and transcobalamin (TC) and their …

Vitamin B 12 is an essential biomolecule that assists in the catalysis of methyl transfer and
radical-based reactions in cellular metabolism. The structure of B 12 is characterized by a …

The processes by which bacteria proactively scavenge essential nutrients in crowded
environments such as the gastrointestinal tract are not fully understood. In this context, we …

In bacteria, many essential metabolic processes are controlled by riboswitches, gene
regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding …

Cyanocobalamin (CNCbl) and aquo/hydroxocobalamin (HOCbl) are the forms of vitamin
B12 that are most commonly used for supplementation. They are both converted to …

Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …

Cobamides are a family of enzyme cofactors that are required by organisms in all domains
of life. Over a dozen cobamides exist in nature although only cobalamin (vitamin B 12), the …

Background Methylmalonic acidemia (MMA) is a rare inherited metabolic disease caused by
methylmalonyl-CoA deficiency or cobalamin metabolism disorder. It is mainly inherited in …

Antivitamins B 12 have been designed as agents inducing B 12-deficiency by counteracting
the metabolic effects of vitamin B 12 and related cobalamins (Cbls). As expressed by our …

Adenyl cobamide (commonly known as pseudovitamin B12) is synthesized by intestinal
bacteria or ingested from edible cyanobacteria. The effect of pseudovitamin B12 on the …