Numerous genetic loci have been associated with systolic blood pressure (SBP) and
diastolic blood pressure (DBP) in Europeans 1, 2, 3. We now report genome-wide …

Because metabolites are hypothesized to play key roles as markers and effectors of
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health
problem, and the assessment of genetic factors influencing kidney function has substantial …

The biological clock, the suprachiasmatic nucleus (SCN), is essential for our daily well-
being. It prepares us for the upcoming period of activity by an anticipatory rise in heart rate …

Uromodulin (Tamm–Horsfall protein) is the most abundant protein excreted in the urine
under physiological conditions. It is exclusively produced in the kidney and secreted into the …

Small molecules are extensively metabolized and cleared by the kidney. Changes in serum
metabolite concentrations may result from impaired kidney function and can be used to …

Alstrom syndrome is a rare autosomal recessive genetic disorder characterized by cone-rod
dystrophy, hearing loss, childhood truncal obesity, insulin resistance and hyperinsulinemia …

Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes
and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or …

Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …