Genome-wide association studies with metabolomics (mGWAS) identify genetically
influenced metabotypes (GIMs), their ensemble defining the heritable part of every human's …

Purpose: Knowledge of transporters responsible for the renal secretion of creatinine is key to
a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …

Various endogenous probes have been identified for a number of hepatic and renal drug
transporters and available clinical data indicate that they could be leveraged in phase I trials …

A genome-wide association study was performed using the Affymetrix 6.0 chip to identify
genes associated with diabetic nephropathy in African Americans. Association analysis was …

Acute kidney injury (AKI) is characterized by an acute decline in renal function and is
associated to increased mortality rate, hospitalization time, and total health-related costs …

HapMap imputed genome-wide association studies (GWAS) have revealed> 50 loci at
which common variants with minor allele frequency> 5% are associated with kidney …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Renal tubulointerstitial fibrosis is the final common pathway of progressive renal diseases. In
allografts, it is assessed with tubular atrophy as interstitial fibrosis/tubular atrophy (IF/TA) …