Unrelated disease processes commonly occur in non-diabetic individuals with mild-to-
moderate hypertension and low level or absent proteinuria who present with chronic kidney …

Homoarginine (hArg) is an endogenous, nonproteinogenic amino acid which differs from
arginine by an additional methylene (CH 2) group in the backbone. In this brief narrative …

Abstract Background Uromodulin (Tamm–Horsfall protein) is the most abundant protein
excreted in the urine under physiological conditions. It is exclusively produced in the kidney …

We sought to comprehensively and systematically characterize the relationship between
genetic variation, miRNA expression, and mRNA expression. Genome-wide expression …

The identification of genetic factors associated with kidney disease has the potential to
provide critical insights into disease mechanisms. Genome-wide association studies have …

In this review encouraged by original data, we first provided in vivo evidence that the kidney,
comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the …

Uromodulin, the major protein secreted in normal urine, is exclusively produced in the thick
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …

The asymmetric methylarginines inhibit nitric oxide synthesis in vivo by competing with L-
arginine at the active site of nitric oxide synthase. High circulating levels of asymmetric …

Chronic kidney disease (CKD) is an aging-related disorder that represents a major global
public health burden. Current biochemical biomarkers, such as serum creatinine and urinary …

Accumulation of advanced glycation endproducts (AGEs) is linked to decline in renal
function, particularly in patients with diabetes. Major forms of AGEs in serum are protein …