Phosphodiesterase 2 (PDE2) is a ubiquitous enzyme whose major role is to hydrolyze the
important second messengers cyclic adenosine monophosphate (cAMP) and cyclic …

This revision of previous algorithms for the pharmacotherapy of generalized anxiety disorder
was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore …

Background Despite their widespread use, the biological mechanisms underlying the
efficacy of psychotropic drugs are still incompletely known; improved understanding of these …

The present study seeks to evaluate the sedative and anxiolytic effects of the 70% ethanol
extract of Sinomeni Caulis et Rhizoma (SR). The extract was orally administered to mice at …

Brain-derived neurotrophic factor (BDNF) is known to promote fear learning as well as
avoidant behavioral responses to chronic social defeat stress, but, conversely, this peptide …

Background A growing body of evidence suggests that deficits in GABAergic inhibitory and
glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of …

Anxiety disorders are common among patients in primary care and share a common thread:
focusing on future threats. Worry, avoidant behavior or behavioral adaptations, and …

Background Although not approved for the treatment of anxiety disorders (except
trifluoperazine) there is ongoing off‐label, unapproved use of first‐generation antipsychotics …

Although antidepressant drugs do not differ much in their efficacy rates, the particular
characteristics of one drug may make it a better choice in a given patient. This article …

The separation-induced vocalization test in guinea pig pups is one of many that has been
used to screen for anxiolytic-like properties of drugs. The test is based on the cross-species …