The roles of phosphodiesterase 2 in the central nervous and peripheral systems
C Zhang, Y Yu, L Ruan, C Wang, J Pan… - Current …, 2015 - ingentaconnect.com
Phosphodiesterase 2 (PDE2) is a ubiquitous enzyme whose major role is to hydrolyze the
important second messengers cyclic adenosine monophosphate (cAMP) and cyclic …
important second messengers cyclic adenosine monophosphate (cAMP) and cyclic …
The psychopharmacology algorithm project at the Harvard South Shore Program: an algorithm for generalized anxiety disorder
HR Abejuela, DN Osser - Harvard Review of Psychiatry, 2016 - journals.lww.com
This revision of previous algorithms for the pharmacotherapy of generalized anxiety disorder
was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore …
was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore …
[HTML][HTML] Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs
Background Despite their widespread use, the biological mechanisms underlying the
efficacy of psychotropic drugs are still incompletely known; improved understanding of these …
efficacy of psychotropic drugs are still incompletely known; improved understanding of these …
The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice
JBI de la Peña, HL Lee, SY Yoon, GH Kim… - Journal of natural …, 2013 - Springer
The present study seeks to evaluate the sedative and anxiolytic effects of the 70% ethanol
extract of Sinomeni Caulis et Rhizoma (SR). The extract was orally administered to mice at …
extract of Sinomeni Caulis et Rhizoma (SR). The extract was orally administered to mice at …
Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress
AM Rosenhauer, LQ Beach, EC Jeffress… - …, 2019 - Elsevier
Brain-derived neurotrophic factor (BDNF) is known to promote fear learning as well as
avoidant behavioral responses to chronic social defeat stress, but, conversely, this peptide …
avoidant behavioral responses to chronic social defeat stress, but, conversely, this peptide …
Cortical inhibitory and excitatory function in drug-naive generalized anxiety disorder
Background A growing body of evidence suggests that deficits in GABAergic inhibitory and
glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of …
glutamatergic excitatory neurotransmission may be involved in the core pathophysiology of …
[PDF][PDF] Generalized anxiety disorder
WA Kehoe - ACSAP, 2017 - accp.com
Anxiety disorders are common among patients in primary care and share a common thread:
focusing on future threats. Worry, avoidant behavior or behavioral adaptations, and …
focusing on future threats. Worry, avoidant behavior or behavioral adaptations, and …
Antipsychotic agents in anxiety disorders: An umbrella review
A Garakani, FD Buono, M Salehi… - Acta Psychiatrica …, 2024 - Wiley Online Library
Background Although not approved for the treatment of anxiety disorders (except
trifluoperazine) there is ongoing off‐label, unapproved use of first‐generation antipsychotics …
trifluoperazine) there is ongoing off‐label, unapproved use of first‐generation antipsychotics …
A practical approach to prescribing antidepressants.
E Shultz, DA Malone Jr - Cleveland Clinic Journal of Medicine, 2013 - europepmc.org
Although antidepressant drugs do not differ much in their efficacy rates, the particular
characteristics of one drug may make it a better choice in a given patient. This article …
characteristics of one drug may make it a better choice in a given patient. This article …
[HTML][HTML] Pharmacological and methodological aspects of the separation-induced vocalization test in guinea pig pups; a systematic review and meta-analysis
L Groenink, PM Verdouw, B Bakker… - European journal of …, 2015 - Elsevier
The separation-induced vocalization test in guinea pig pups is one of many that has been
used to screen for anxiolytic-like properties of drugs. The test is based on the cross-species …
used to screen for anxiolytic-like properties of drugs. The test is based on the cross-species …