Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by
all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

As neurons are highly energy-demanding cell, increasing evidence suggests that
mitochondria play a large role in several age-related neurodegenerative diseases. Synaptic …

RNA-binding proteins (RBPs) are key players regulating RNA processing and are
associated with disorders ranging from cancer to neurodegeneration. Here, we present a …

Genome-wide association studies (GWASs) have identified numerous susceptibility loci for
Parkinson's disease (PD), but its genetic architecture remains underexplored in populations …

Huntington's disease results from expansion of a glutamine-coding CAG tract in the
huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and …

Multiple neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's
disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are being …