Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

Although altered glycosylation has been detected in human cancer cells decades ago, only
investigations in the last years have enormously increased our knowledge about the details …

Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents
of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many …

Lysosomal storage diseases (LSDs) are a group of rare, life-threatening genetic disorders,
usually caused by a dysfunction in one of the many enzymes responsible for intralysosomal …

The geographic origins of populations can be identified by their maternally inherited
mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic …

Xylan is the second most abundant polysaccharide in plant biomass. It is a crucial
component of cell wall structure as well as a significant factor contributing to biomass …