Abstract Fumonisin B1 (FB1) is a widely present mycotoxin that accumulates in biological
systems and poses a health risk to animals. However, few studies have reported the …

Biogenesis of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial
respiratory chain, is a complex process facilitated by several assembly factors. Pathogenic …

Maturation of cytochrome oxidases is a complex process requiring assembly of several
subunits and adequate uptake of the metal cofactors. Two orthologous Sco proteins (Sco1 …

Pathogenic variants impacting upon assembly of mitochondrial respiratory chain Complex IV
(Cytochrome c Oxidase or COX) predominantly result in early onset mitochondrial disorders …

The mitochondrial cytochrome c oxidase, the terminal enzyme of the respiratory chain,
contains heme and copper centers for electron transfer. The conserved COX2 subunit …

Cytochrome c oxidase (COX) was initially purified more than 70 years ago. A tremendous
amount of insight into its structure and function has since been gleaned from biochemical …

Mitochondrial disorders represent a heterogeneous group of genetic disorders with
variations in severity and clinical outcomes, mostly characterized by respiratory chain …

The endosymbiotic theory posits that ancient eukaryotic cells engulfed O 2-consuming
prokaryotes, which protected them against O 2 toxicity. Previous studies have shown that …

Mitochondrial metabolism plays an important role in the occurrence and development of
cancers. Cytochrome C oxidase assembly factor six (COA6) is essential in mitochondrial …

Oxidative phosphorylation is a tightly regulated process in mammals that takes place in and
across the inner mitochondrial membrane and consists of the electron transport chain and …