Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery
KV Dileep, K Ihara, C Mishima-Tsumagari… - International Journal of …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the most common, progressive neurodegenerative
disorders affecting the aged populations. Though various disease pathologies have been …
disorders affecting the aged populations. Though various disease pathologies have been …
[HTML][HTML] De novo prediction of explicit water molecule positions by a novel algorithm within the protein design software MUMBO
M Kriegel, YA Muller - Scientific Reports, 2023 - nature.com
By mediating interatomic interactions, water molecules play a major role in protein–protein,
protein–DNA and protein–ligand interfaces, significantly affecting affinity and specificity. This …
protein–DNA and protein–ligand interfaces, significantly affecting affinity and specificity. This …