High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …

Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells
(CICs; also known as cancer stem cells), which constitute the minority of cells within the …

Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity
in cancer and understanding the role of rare cells in tumor progression. These methods …

The ultimate goal of drug delivery research is to help patients by developing clinically useful
formulations. During the last several decades controlled drug delivery technology has …

Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Melanomas are highly heterogeneous tumors, but the biological significance of their
different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU …

Little is known of the genetic architecture of cancer at the subclonal and single-cell level or
in the cells responsible for cancer clone maintenance and propagation. Here we have …

Properties of the small group of cancer cells called tumor-initiating or cancer stem cells
(CSCs) involved in drug resistance, metastasis and relapse of cancers can significantly …