In the last decade, B 12-dependent radical SAM enzymes have emerged as central
biocatalysts in the biosynthesis of a myriad of natural products. Notably, these enzymes …

Objectives Future primary prevention strategies may benefit from understanding the
connection between mortality in individuals with central obesity and modifiable lifestyle …

DFT calculations with the well-tested OLYP and B3LYP* exchange-correlation functionals
(along with D3 dispersion corrections and all-electron ZORA STO-TZ2P basis sets) and …

TsrM is a radical S-adenosylmethionine (SAM) methylase that catalyzes the C2 methylation
of L-tryptophan to produce 2-methyltryptophan, an intermediate in the biosynthesis of the …

代谢紊乱被认为是所有肿瘤细胞的基本特征, 细胞代谢相关调控基因已逐渐成为肿瘤诊断和治疗
的靶点. 一碳代谢是细胞普遍存在的代谢过程, 主要负责机体生物合成, 氨基酸稳态 …

抄録 The bioinspired catalyst system was developed in the interdisciplinary fields of
bioinorganic chemistry and catalytic chemistry. In nature, enzymes catalyze various …