Objectives This study aims to summarise the evidence on more than 140 pharmacological
and non-pharmacological treatment options for major depressive disorder (MDD) and to …

Depression is the primary emotional condition for which help is sought. Depressed people
often report persistent rumination, which involves analysis, and complex social problems in …

Many people identified as having common mental disorders in community surveys do not
receive treatment. Modelling has suggested that closing this “treatment gap” should reduce …

Few studies have delineated the real-world, long-term trends of prescription patterns of
antidepressants for patients with major depressive disorder (MDD). This study aims to …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on the comparative effectiveness of …

Context Psychotropic medication polypharmacy is common in psychiatric outpatient settings
and, in some patient groups, may have increased in recent years. Objective To examine …

Objective: To assess the trend in long-term use of antidepressants by persons aged≥ 18
years, and the correlates of such use, in the United States from 1999 to 2010. Method: We …

Placebo response in clinical trials of antidepressant medications is substantial and has been
increasing. High placebo response rates hamper efforts to detect signals of efficacy for new …

Methods The Canadian Task Force on Preventive Health Care is an independent panel of
clinicians and methodologists that makes recommendations about clinical manoeuvres …

The first comprehensive history of" psychiatry's bible"—the Diagnostic and Statistical Manual
of Mental Disorders. Over the past seventy years, the Diagnostic and Statistical Manual of …