Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …

Significance: Optical imaging using the endogenous fluorescence of metabolic cofactors has
enabled nondestructive examination of dynamic changes in cell and tissue function both in …

Monitoring subcellular functional and structural changes associated with metabolism is
essential for understanding healthy tissue development and the progression of numerous …

Fluorescent bioprobes play an important role in preclinical and clinical practice. During the
past few years, a distinguished type of organic luminogen with aggregation‐induced …

Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant
solid tumors. CM is characterized by a remarkable metabolic plasticity and an important …

Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous
melanoma accounts for a minority of all types of skin cancer, it causes the greatest number …

Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage,
involving complicated cell-matrix interactions. Systematic investigations of dynamic cellular …

Reactive oxygen species (ROS) are emerging as important regulators of cancer growth and
metastatic spread. However, how cells integrate redox signals to affect cancer progression is …

Vitiligo is an autoimmune skin disease characterized by the destruction of melanocytes by
autoreactive CD8+ T cells. Melanocyte destruction in active vitiligo is mediated by CD8+ T …