After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found.
In this review, basic and clinical evidence is presented that assembles and hypothetically …

Recent ultrastructural studies demonstrate characteristic and extensive angioarchitectural
distortions of cerebral capillaries in Alzheimer's brains. Alzheimer's disease subjects …

Background Systolic hypertension increases the risk of dementia in elderly people. The
vascular dementia project, set up in the framework of the double-blind placebo-controlled …

Among neurologically normal volunteers approaching age 65 with an option for retirement, a
four‐year prospective longitudinal study was designed to examine effects of different levels …

Methods. Subjects and setting. Patients were recruited among those aged> 60 years who
were consecutively ad-mitted to Columbia-Presbyterian Medical Center between September …

Computed tomography and magnetic resonance imaging in the elderly have demonstrated
the common occurrence of deep white-matter lesions in the aging brain. These radiologic …

The effects of chronic cerebral hypoperfusion induced by permanent occlusion of bilateral
common carotid arteries (2VO) on learning and memory performance were examined in rats …

It is a privilege to be asked to write the foreword for so excellent a book, so timely and so
much needed by the field. Not only is it most unusual these days to have a single authored …

Global cerebral blood flow, oxidative brain metabolism, and the cerebral arteriovenous
differences of amino acids and ammonia were studied in 20 clinically diagnosed patients …

Forty‐two elderly patients (mean age, 66.2±5.1 yr) with hypertension, treated for an average
of 17.3 years (standard deviation, 10.3), and 42 control subjects (mean age, 66.5±4.8 yr) …