PD-1 and PD-L1 are crucial regulators of immunity expressed on the surface of T cells and
tumour cells, respectively. Cancer cells frequently use PD-1/PD-L1 to evade immune …

Type I interferons have long been appreciated as a cytokine family that regulates antiviral
immunity. Recently, their role in eliciting antitumor immune responses has gained increasing …

Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …

Renal cell carcinoma (RCC) is one of the most lethal genitourinary cancers, with the highest
mortality rate, and may remain undetected throughout its development. RCC can be …

Oncolytic virus (OV) therapy is a promising virus-based approach against various
malignancies, including pancreatic ductal adenocarcinoma (PDAC). Our previous studies …

Background Currently, cytokine therapy for cancer has demonstrated efficacy in certain
diseases but is generally accompanied by severe toxicity. The field of antibody-cytokine …

Abstract Background Mesenchymal stem cells (MSCs) have garnered significant interest for
their tumor-tropic property, making them potential therapeutic delivery vehicles for cancer …

Interleukin-7 (IL-7) is essential for maintaining the immune system's defense functions by
regulating the development and homeostasis of lymphocytes. Findings have shown the high …

Background Class I selective histone deacetylase inhibitors (HDACi) have been previously
demonstrated to not only increase major histocompatibility complex class I surface …

Immunotherapy with interferon-α (IFN-α) is frequently associated with neuropsychiatric
consequences, including depression. Mechanisms underlying adverse effects of IFN-α are …