Immunomodulatory effects of (24R)-pseudo-ginsenoside HQ and (24S)-pseudo-ginsenoside HQ on cyclophosphamide-induced immunosuppression and their anti …

Z Qi, L Chen, Z Li, Z Shao, Y Qi, K Gao, S Liu… - International journal of …, 2019 - mdpi.com
(24R)-pseudo-ginsenoside HQ (R-PHQ) and (24S)-pseudo-ginsenoside HQ (S-PHQ) are
the main metabolites of (20S)-ginsenoside Rh2 (Rh2) in vivo. In this study, we found that …

Stereospecificity of Ginsenoside Rg3 in the promotion of cellular immunity in hepatoma H22‐bearing mice

R Wu, Q Ru, L Chen, B Ma, C Li - Journal of Food Science, 2014 - Wiley Online Library
Previous investigations have demonstrated that ginsenoside Rg3 (Rg3) has many actions
including antitumor, antioxidative, and immunomodulatory effects. However, Rg3 exists as 2 …

The immunomodulatory effects of ginsenoside derivative Rh2-O on splenic lymphocytes in H22 tumor-bearing mice is partially mediated by TLR4

H Wu, Q Hu, T Luo, W Wei, H Wu, J Li, L Zheng… - International …, 2021 - Elsevier
Purpose Previously, we reported the octyl ester derivative of ginsenoside Rh2 (Rh2-O) had
better antitumor and immunomodulatory effects than Rh2 in H22 tumor-bearing mice …

Antitumor and immunomodulatory effects of ginsenoside Rh2 and its octyl ester derivative in H22 tumor-bearing mice

F Chen, Y Sun, SL Zheng, Y Qin, DJ McClements… - Journal of functional …, 2017 - Elsevier
Ginsenoside Rh2 is a major metabolite from ginseng that has antitumor activity. Previously,
we reported that Rh2-O, an octyl ester derivative of ginsenoside Rh2, had a higher anti …

Immunomodulatory effect of ginsenoside Rb2 against cyclophosphamide-induced immunosuppression in mice

S Zheng, H Zheng, R Zhang, X Piao, J Hu… - Frontiers in …, 2022 - frontiersin.org
Ginsenoside Rb2 (Rb2), a fundamental saponin produced and isolated from ginseng
(Panax ginseng CA Meyer), has a wide range of biological actions. The objective of this …

Ginsenoside Rg3 improves cyclophosphamide-induced immunocompetence in Balb/c mice

X Liu, Z Zhang, J Liu, Y Wang, Q Zhou, S Wang… - International …, 2019 - Elsevier
Abstract Ginsenoside Rg3 (Rg3), which comprises Panax ginseng, is commonly used to
improve the immunocompetence of cancer patients undergoing chemotherapy. This study …

Antitumoral activity of (20R)-and (20S)-ginsenoside Rh2 on transplanted hepatocellular carcinoma in mice

Q Lv, N Rong, LJ Liu, XL Xu, JT Liu, FX Jin… - Planta …, 2016 - thieme-connect.com
Hepatocellular carcinoma is one of the leading causes of malignancy-related death in
China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable …

Sulfated derivatives of 20 (S)-ginsenoside Rh2 and their inhibitory effects on LPS-induced inflammatory cytokines and mediators

BD Fu, WY Bi, CL He, W Zhu, HQ Shen, PF Yi, L Wang… - Fitoterapia, 2013 - Elsevier
Ginsenoside Rh2 is one of the most important ginsenosides in ginseng with antitumor,
antidiabetic, antiallergic, and anti-inflammatory effects. However, the extremely poor oral …

Ginsenoside Rh2-B1 stimulates cell proliferation and IFN-γ production by activating the p38 MAPK and ERK-dependent signaling pathways in CTLL-2 cells

S Lv, PF Yi, HQ Shen, LY Zhang, HB Dong… - …, 2014 - Taylor & Francis
Abstract Context: Ginsenoside Rh2, an active component of ginseng, exhibits
immunoregulatory and anti-inflammatory properties. Rh2-B1, a sulfated derivative, was …

[PDF][PDF] Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells

J Yu, D Dou, X Chen, H Yang, N Guo… - Acta Pharmacologica …, 2004 - researchgate.net
ABSTRACT AIM: To investigate the immunoenhancing activity of ginsenoside-F3 in murine
spleen cells and explore its mechanism. METHODS: The enhancing effect of ginsenoside …