Efficient microscale synthesis of [18F]-2-fluoro-2-deoxy-d-glucose

MC Koag, HK Kim, AS Kim - Chemical Engineering Journal, 2014 - Elsevier
Microscale radiosynthesis of [18 F] FDG using a miniaturized device has been reported as a
promising tool for positron emission tomography. However, small scale [18 F] FDG …

Efficiently automated synthesis of 2-[18F]-fluoro-2-deoxy-D-glucose

G Tang, M Wang, X Guo, X Tang - Nuclear Techniques, 2006 - inis.iaea.org
[en] Automated synthetic technology of 2-[18 F]-fluoro-2-deoxy-D-glucose (18 F-FDG) was
described. Automated synthesis of 18 F-FDG wa performed by'one-pot'and'two-step …

Rapid synthesis of [18F] FDG without an evaporation step using an ionic liquid

HW Kim, JM Jeong, YS Lee, DY Chi, KH Chung… - Applied radiation and …, 2004 - Elsevier
In this study, we describe a new 2-[18F] fluoro-2-deoxy-d-glucose ([18F] FDG) synthesis
without a distillation step. This involves fluorinating in an ionic liquid-containing medium. A …

Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip

H Kimura, K Tomatsu, H Saiki, K Arimitsu, M Ono… - PLoS …, 2016 - journals.plos.org
In the field of positron emission tomography (PET) radiochemistry, compact microreactors
provide reliable and reproducible synthesis methods that reduce the use of expensive …

Alternative synthesis of no‐carrier‐added 2‐deoxy‐2‐[18F]fluoro‐D‐glucose using [18F] fluoride ion

T Haradahira, M Maeda… - Journal of Labelled …, 1988 - Wiley Online Library
Two alternative routes to no‐carrier‐added synthesis of 2‐deoxy‐2‐[18F] fluoro‐D‐glucose
(2‐18FDG) involving nucleophilic displacements of methyl 3‐O‐benzyl‐4, 6‐O‐benzylidene …

[PDF][PDF] AN IMPROVED METHODOLOGY FOR DETERMINATION OF RADIOCHEMICAL AND CHEMICAL IMPURITIES IN THE SYNTHESIS PROCESS OF 18 F-FDG (2 …

M Mihon, C Tuta, R Leonte, AC Ion… - Environmental …, 2015 - researchgate.net
Abstract 18F-FDG is a glucose analog in which the hydroxyl group on the second carbon is
substituted with 18F, being used as an indicator of glucose uptake and cell viability. The aim …

Purification of 2-[18F] fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction

MD Tarn, G Pascali, F De Leonardis, P Watts… - … of Chromatography A, 2013 - Elsevier
Microfluidic devices have shown great potential for the production of positron emission
tomography (PET) radiotracers, but most devices have focused only on the synthesis step of …

Fast and efficient microscale radiosynthesis of 3′-deoxy-3′-[18F] fluorothymidine

MC Koag, HK Kim, AS Kim - Journal of Fluorine Chemistry, 2014 - Elsevier
Microscale radiosynthesis on a miniaturized device has been reported as a promising tool
for positron emission tomography. Here, we studied miscroscale-level radiosynthetic …

Increased [18F] 2-fluoro-2-deoxy-d-glucose ([18F] FDG) yield with recycled target [18O] water: factors affecting the [18F] FDG yield

K Nishijima, Y Kuge, E Tsukamoto, K Seki… - Applied radiation and …, 2002 - Elsevier
The reuse of [18O] water after being purified by distillation has been reported to give lower
[18F] 2-fluoro-2-deoxy-d-glucose ([18F] FDG) yields, probably due to the presence of …

Basic hydrolysis of 2-[18F] fluoro-1, 3, 4, 6-tetra-O-acetyl-D-glucose in the preparation of 2-[18F] fluoro-2-deoxy-D-glucose

F Füchtner, J Steinbach, P Mäding… - Applied Radiation and …, 1996 - Elsevier
In contrast to the commonly used acid hydrolysis of 2-[18F] fluoro-1, 3, 4, 6-tetra-O-acetyl-d-
glucose to [18F] FDG, basic hydrolysis is a short, high-yield procedure at room temperature …