Different mutational processes leave characteristic patterns of somatic mutations in the
genome that can be identified as mutational signatures. Determining the contributions of …

Background In the past decade, systematic and comprehensive analyses of cancer
genomes have identified cancer driver genes and revealed unprecedented insight into the …

Background Mutational signatures have been proved as a valuable pattern in somatic
genomics, mainly regarding cancer, with a potential application as a biomarker in clinical …

Cancer is a genetic disease caused by somatic mutations; however, the understanding of
the causative biological processes generating these mutations is limited. A cancer genome …

Mutational signatures are recurring DNA alteration patterns caused by distinct mutational
events during the evolution of cancer. In recent years, several bioinformatics tools are …

Motivation Analysis of mutational signatures is a powerful approach for understanding the
mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the …

Abstract Analysis of cancer mutational signatures have been instrumental in identification of
responsible endogenous and exogenous molecular processes in cancer. The quantitative …

Somatic mutations in cancer genomes are caused by multiple mutational processes each of
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …

Mutational signatures are patterns of mutations that arise during tumorigenesis. We present
an enhanced, practical framework for mutational signature analyses. Applying these …

Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …