Multi-ancestry genome-wide association meta-analysis of mosaic loss of chromosome Y in the Million Veteran Program identifies 167 novel loci
Mosaic loss of chromosome Y (mLOY) is a common somatic mutation in leukocytes of older
males. mLOY was detected in 126,108 participants of the Million Veteran Program: 106,054 …
males. mLOY was detected in 126,108 participants of the Million Veteran Program: 106,054 …
Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood
YA Jakubek, X Ma, AM Stilp, F Yu, J Bacon, JW Wong… - medRxiv, 2024 - medrxiv.org
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in
human blood. The presence of mLOY is associated with altered blood cell counts and …
human blood. The presence of mLOY is associated with altered blood cell counts and …
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
C Terao, Y Momozawa, K Ishigaki, E Kawakami… - Nature …, 2019 - nature.com
Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
men. However, the genetic architecture and biological mechanisms underlying mLOY are …
A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells
Background Mosaic loss of Y chromosome (LOY) is the most common somatic change that
occurs in circulating white blood cells of older men. LOY in leukocytes is associated with …
occurs in circulating white blood cells of older men. LOY in leukocytes is associated with …
Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
Mosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
somatic event. Previous studies have indicated age and cigarette smoking increase the risk …
Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism, yet our knowledge of the causes and consequences of this is …
form of clonal mosaicism, yet our knowledge of the causes and consequences of this is …
Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential …
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
The Y chromosome is frequently lost in hematopoietic cells, which represents the most
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …
common somatic alteration in men. However, the mechanisms that regulate mosaic loss of …
Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
M Danielsson, J Halvardson, H Davies… - European Journal of …, 2020 - nature.com
Mosaic loss of chromosome Y (LOY) is the most common somatic genetic aberration and is
associated with increased risk for all-cause mortality, various forms of cancer and …
associated with increased risk for all-cause mortality, various forms of cancer and …
[HTML][HTML] Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells
Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in
hematopoietic cells in men. However, due to the high prevalence of LOY as the sole …
hematopoietic cells in men. However, due to the high prevalence of LOY as the sole …