A number of genetic disorders are caused by mutations in the genes encoding
glycosyltransferases and sulfotransferases, enzymes responsible for the synthesis of …

Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …

Glycosaminoglycans (GAG s) are a heterogeneous family of linear polysaccharides that
constitute the carbohydrate moiety covalently attached to the protein core of proteoglycans …

Glycosaminoglycans, including chondroitin, dermatan, and heparan sulfate, have various
roles in a wide range of biological events such as cell signaling, cell proliferation, tissue …

The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been
demonstrated in various biological events including construction of the extracellular matrix …

Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated
glycosaminoglycan sidechains of proteoglycans has provided important clues to answering …

Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan
sulfate are covalently attached to specific core proteins to form proteoglycans, which are …

The glycosaminoglycan chondroitin sulfate (CS) consists of long linear chains of repeating
disaccharide units, which are covalently attached to core proteins to form CS-proteoglycans …

Achondrogenesis type 1B is an autosomal recessive, lethal chondrodysplasia caused by
mutations in the gene encoding a sulfate/chloride antiporter of the cell membrane (Superti …

The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and
galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS. Deficiencies of ASB and …