Abstract Background Members of Rho-associated coiled-coil kinases (ROCKs) are effectors
of Rho family of small GTPases. ROCKs have multiple functions that include regulation of …

The regulation of the differentiation of the bone-forming cells, the osteoblasts, is complex.
Many signaling pathways converge on the master regulator of osteoblast differentiation …

The intracellular signaling pathways controlling chondrocyte physiology are largely
unknown. Here we show that the small GTPases, Rac1 and Cdc42, accelerate the rate of …

Coordinated proliferation and differentiation of growth plate chondrocytes is required for
normal growth and development of the endochondral skeleton, but little is known about the …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

RhoGTPases regulate actin cytoskeleton dynamics, a key element in osteoclast biology. We
identified three novel genes induced during RANKL‐stimulated osteoclastogenesis among …

Small G proteins of the Rho family are pivotal regulators of several signaling networks. The
Ras homolog family (Rho) and one of its targets, Rho-associated protein kinase (ROCK) …