Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

The cellular and molecular mechanisms underlying smooth muscle contraction are reviewed
in the light of recent studies of smooth muscle ultrastructure and of the role of …

The relationship between phosphorylation of the 20-kDa myosin light chain, intracellular
calcium levels ([Ca 2+] i), and isometric force was studied during prolonged activation of …

Phosphorylation of the regulatory light chains of myosin II (rMLC) by the Ca2+/calmodulin-
dependent myosin light-chain kinase (MLCK) and dephosphorylation by a type 1 …

Abstract The Ca2+-dependent, reversible phosphorylation of the 20 kDa regulatory myosin
light chain (MLC) plays a primary role in regulating the contraction of smooth muscle …

Many neurohormones alter the force of cardiac contraction by variations in the intracellular
Ca2+ concentration. alpha 1-Adrenergic and muscarinic stimulations, rather, modify the …

An in-depth understanding of the regulation of contractile tone in smooth muscle takes its
form from detailed biochemical descriptions of (a) specific effects unique to individual …

The hypothesis that Ca2+ initiates contraction in smooth muscle by activating an
endogenous myosin light chain kinase (MLCK) that phosphorylates the 20,000 dalton light …

1 Smooth muscle contraction is activated primarily by the Ca2+‐calmodulin (CaM)‐
dependent phosphorylation of the 20 kDa light chains (LC20) of myosin. Activation can also …

Phosphorylation of myosin increases rapidly upon stimulation of an arterial smooth muscle.
However, peak values are not maintained and phosphorylation declines, while active stress …