(1) Background: The effects of short-term social isolation during adulthood have not yet been
fully established in rats behaviourally, and not at all transcriptomically in the medial …

Intact function of the medial prefrontal cortex (mPFC) function relies on proper development
of excitatory and inhibitory neuronal populations and on integral myelination processes …

Chronic stress during the developmental period of adolescence increases susceptibility to
many neuropsychiatric diseases in adulthood, including anxiety, affective, and …

In the early stage of life, experiencing social isolation can generate long-lasting deleterious
effects on behaviors and brain development. However, the effects of chronic social isolation …

Although medial prefrontal cortex (mPFC) is known to play important roles in social
behaviors, how early social experiences affect the mPFC and its subcortical circuit remains …

Social isolation poses a severe mental and physiological burden on humans. Most animal
models that investigate this effect are based on prolonged isolation, which does not mimic …

Early-life social isolation induces emotional and cognitive dysregulation, such as increased
aggression and anxiety, and decreases neuron excitability in the medial prefrontal cortex …

Mice socially isolated during adolescence exhibit behaviors of anxiety, depression and
impaired social interaction. Although these behaviors are well documented, very little is …

The prefrontal cortex (PFC) plays an important role in social behavior and is sensitive to
stressful circumstances. Challenging life conditions might change PFC function and put …

Early life context and stressful experiences are known to increase the risk of developing
psychiatric disorders later in life, including disorders with deficits in the social domain. Our …