Lactate oxidase (LOx) has attracted extensive interest in cancer diagnosis and therapy in
recent years owing to its specific catalysis on l‐lactate; its catalytic process consumes …

Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in
tumors holds great promise for the reversal of the immunosuppressive tumor …

Lactic acid (LA) is a powerful molecule as the metabolic driver in tumor microenvironments
(TMEs). Inspired by its high intratumoral level (5–20 µmol g− 1), a novel treatment paradigm …

Glucose oxidase (GOx) is an endogenous oxido-reductase that is widely distributed in living
organisms. Over recent years, GOx has attracted increasing interest in the biomedical field …

Nanocatalytic tumor therapy is an emerging antitumor option that employs catalytically‐
active inorganic nanostructures to produce tumor‐damaging reactive oxygen species …

Lactate in tumors has long been considered “metabolic junk” derived from the glycolysis of
cancer cells and utilized only as a biomarker of malignancy, but is presently believed to be a …

The aggressive proliferation of tumor cells often requires increased glucose uptake and
excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to …

Designing nanozymes that match natural enzymes have always been an attractive and
challenging goal. In general, researchers mainly focus on the construction of metal centers …

Direct hypoxia alleviation and lactate depletion in the tumor microenvironment (TME) are
promising for effective cancer therapy but still very challenging. To address this challenge …

In this work, a novel amperometric biosensor based on gold nanoparticles anchored on
reduced graphene oxide (RGO-AuNPs) and l-lactate dehydrogenase (LDH) was developed …