Cardiac dysfunction promotes cancer progression via multiple secreted factors
L Awwad, A Aronheim - Cancer research, 2022 - AACR
Heart failure and cancer are the leading cause of deaths worldwide. While heart failure and
cancer have been considered separate diseases, it is becoming evident that they are highly …
cancer have been considered separate diseases, it is becoming evident that they are highly …
Tumor Progression Reverses Cardiac Hypertrophy and Fibrosis in a Tetracycline-Regulated ATF3 Transgenic Mouse Model
L Awwad, A Aronheim - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVD) and cancer are the top deadly diseases in the world. Both
CVD and cancer have common risk factors; therefore, with the advances in treatment and life …
CVD and cancer have common risk factors; therefore, with the advances in treatment and life …
Heart failure stimulates tumor growth by circulating factors
WC Meijers, M Maglione, SJL Bakker, R Oberhuber… - Circulation, 2018 - Am Heart Assoc
Background: Heart failure (HF) survival has improved, and nowadays, many patients with HF
die of noncardiac causes, including cancer. Our aim was to investigate whether a causal …
die of noncardiac causes, including cancer. Our aim was to investigate whether a causal …
Pressure Overload–Induced Cardiac Hypertrophy Stimulates Tumor Growth in Tumor-Prone ApcMin Mice
S De Wit, JP Aboumsallem, C Shi… - Circulation: Heart …, 2023 - Am Heart Assoc
Heart failure (HF) and cancer are leading causes of death worldwide and often coincide. A
growing number of epidemiological studies have shown that patients with HF are at …
growing number of epidemiological studies have shown that patients with HF are at …
Mechanisms underlying the cross‐talk between heart and cancer
M Brancaccio, F Pirozzi, E Hirsch… - The Journal of …, 2020 - Wiley Online Library
Cardiovascular diseases and cancer remain the leading cause of death worldwide. Despite
the fact that these two conditions have long been considered as distinct clinical entities …
the fact that these two conditions have long been considered as distinct clinical entities …
Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice
TE Berent, JM Dorschner, T Meyer, TA Craig, X Wang… - PloS one, 2019 - journals.plos.org
Background To understand the underlying mechanisms of cardiac dysfunction in cancer, we
examined cardiac function, protein synthesis, mitochondrial function and gene expression in …
examined cardiac function, protein synthesis, mitochondrial function and gene expression in …
Cardiac remodeling in the absence of cardiac contractile dysfunction is sufficient to promote cancer progression
L Awwad, T Goldenberg, I Langier-Goncalves… - Cells, 2022 - mdpi.com
Cardiovascular diseases and cancer are the leading cause of death worldwide. The two
diseases share high co-prevalence and affect each other's outcomes. Recent studies …
diseases share high co-prevalence and affect each other's outcomes. Recent studies …
Heart failure post-myocardial infarction promotes mammary tumor growth through the NGF-TRKA pathway
T Tani, M Oikawa, T Misaka, T Ishida, Y Takeishi - Cardio Oncology, 2024 - jacc.org
Background Epidemiological investigations suggest that patients with heart failure have a
higher incidence of cancer; however, the causal role of cardiac disease on cancer …
higher incidence of cancer; however, the causal role of cardiac disease on cancer …
Early cardiac remodeling promotes tumor growth and metastasis
Background: Recent evidence suggests that cancer and cardiovascular diseases are
associated. Chemotherapy drugs are known to result in cardiotoxicity, and studies have …
associated. Chemotherapy drugs are known to result in cardiotoxicity, and studies have …
[引用][C] ATF3, a novel cardiac therapeutic target: Beneficial or harmful?
R Kalfon, L Koren, A Aronheim - International …, 2017 - internationaljournalofcardiology.com
Using phenylephrine infusion pressure overload model, we have shown that ATF3
expression promotes cardiac maladaptive processes [1–3]. The mechanism suggested …
expression promotes cardiac maladaptive processes [1–3]. The mechanism suggested …