[HTML][HTML] Therapeutic and prognostic insights from the analysis of cancer mutational signatures
The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
[HTML][HTML] Portrait of a cancer: mutational signature analyses for cancer diagnostics
Background In the past decade, systematic and comprehensive analyses of cancer
genomes have identified cancer driver genes and revealed unprecedented insight into the …
genomes have identified cancer driver genes and revealed unprecedented insight into the …
Mutational signatures: emerging concepts, caveats and clinical applications
Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
[HTML][HTML] Mutational signatures: experimental design and analytical framework
Mutational signatures provide a powerful alternative for understanding the pathophysiology
of cancer. Currently, experimental efforts aimed at validating and understanding the …
of cancer. Currently, experimental efforts aimed at validating and understanding the …
Mechanisms underlying mutational signatures in human cancers
The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …
mutagenic processes that have been operative over the lifetime of a patient. Each process …
The repertoire of mutational signatures in human cancer
Somatic mutations in cancer genomes are caused by multiple mutational processes each of
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …
[HTML][HTML] Domain landscapes of somatic mutations in cancer
NL Nehrt, TA Peterson, DH Park, MG Kann - BMC genomics, 2012 - Springer
Background Large-scale tumor sequencing projects are now underway to identify genetic
mutations that drive tumor initiation and development. Most studies take a gene-based …
mutations that drive tumor initiation and development. Most studies take a gene-based …
[HTML][HTML] MutSignatures: an R package for extraction and analysis of cancer mutational signatures
Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and
other mechanisms. Different genetic instability processes result in characteristic non-random …
other mechanisms. Different genetic instability processes result in characteristic non-random …
A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies
A Degasperi, TD Amarante, J Czarnecki, S Shooter… - Nature cancer, 2020 - nature.com
Mutational signatures are patterns of mutations that arise during tumorigenesis. We present
an enhanced, practical framework for mutational signature analyses. Applying these …
an enhanced, practical framework for mutational signature analyses. Applying these …
Understanding mutagenesis through delineation of mutational signatures in human cancer
M Petljak, LB Alexandrov - Carcinogenesis, 2016 - academic.oup.com
Each individual cell within a human body acquires a certain number of somatic mutations
during a course of its lifetime. These mutations originate from a wide spectra of both …
during a course of its lifetime. These mutations originate from a wide spectra of both …