The objective of current treatments for various myopathies is to interrupt the signal from the
brain to the affected muscle group, providing relief. To prevent unwanted side effects and …

Inhibitors of muscle myosin ATPases are needed to treat conditions that could be improved
by promoting muscle relaxation. The lead compound for this study ((3-(N-butylethanimidoyl) …

Myosin II is an interesting target for therapeutic intervention, as it is involved in a large
number of motility-based diseases.(S)-Blebbistatin is a known micromolar inhibitor of this …

As mentioned in the Literature overview,(S)-blebbistatin (S)-4 has two main disadvantages
which limit its application as a research tool in cell biology:(i) low water solubility (and …

(S)-Blebbistatin, a chiral tetrahydropyrroloquinolinone, is a widely used and well-
characterized ATPase inhibitor selective for myosin II. The central role of myosin II in many …

Abstract (S)-Blebbistatin is a micromolar myosin II ATPase inhibitor that is extensively used
in research. In search of analogs with improved potency, we have synthesized for the first …

Myosin 2 inhibition and the traditional myosin 2 inhibitor, blebbistatin have recently become
the focus of interest of drug discovery and drug development. The effect of several …

In search of myosin II inhibitors with superior research tool properties, a chemical
optimization campaign of the blebbistatin scaffold was conducted in this paper.(S) …

Blebbistatin, para-nitroblebbistatin (NBleb) and para-aminoblebbistatin (AmBleb) are highly
useful tool compounds as they selectively inhibit the ATPase activity of myosin-2 family …

The eukaryotic cell nanomotors are able to perform many complex mechanical tasks,
necessary for tension generation in precise cellular locations such as transport or …