[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows
that outcomes are markedly heterogeneous between patients. This requires identifying the …
that outcomes are markedly heterogeneous between patients. This requires identifying the …
[HTML][HTML] COVID-19 through adverse outcome pathways: Building networks to better understand the disease–3rd CIAO AOP design workshop
Abstract On April 28–29, 2021, 50 scientists from different fields of expertise met for the 3 rd
online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using …
online CIAO workshop. The CIAO project “Modelling the Pathogenesis of COVID-19 using …
[HTML][HTML] The landscape of abnormal pathway activation confers COVID-19 patients' molecular sequelae earlier than clinical phenotype
X Zhang, Y Sh, J Dong, Z Chen, F Hong - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: The 2019 coronavirus disease (COVID-19) pandemic poses a significant threat to
human health. After SARS-CoV-2 infection, major clinical concerns are organ damage and …
human health. After SARS-CoV-2 infection, major clinical concerns are organ damage and …
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
Systematic organization of COVID-19 data supported by the adverse outcome pathway framework
Adverse Outcome Pathways (AOP) provide structured frameworks for the systematic
organization of research data and knowledge. The AOP framework follows a set of key …
organization of research data and knowledge. The AOP framework follows a set of key …
Comorbidities and clinical complications associated with SARS-CoV-2 infection: an overview
A Gupta, H Marzook, F Ahmad - Clinical and experimental medicine, 2023 - Springer
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes major
challenges to the healthcare system. SARS-CoV-2 infection leads to millions of deaths …
challenges to the healthcare system. SARS-CoV-2 infection leads to millions of deaths …
Predicting COVID-19—comorbidity pathway crosstalk-based targets and drugs: towards personalized COVID-19 management
It is well established that pre-existing comorbid conditions such as hypertension, diabetes,
obesity, cardiovascular diseases (CVDs), chronic kidney diseases (CKDs), cancers, and …
obesity, cardiovascular diseases (CVDs), chronic kidney diseases (CKDs), cancers, and …
Clinical predictors of COVID-19 severity and mortality: a perspective
The COVID-19 pandemic has caused huge socio-economic losses and continues to threat
humans worldwide. With more than 4.5 million deaths and more than 221 million confirmed …
humans worldwide. With more than 4.5 million deaths and more than 221 million confirmed …
Molecular and clinical prognostic biomarkers of COVID-19 severity and persistence
G Papadopoulou, E Manoloudi, N Repousi, L Skoura… - Pathogens, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), poses several challenges to clinicians, due to its …
syndrome coronavirus-2 (SARS-CoV-2), poses several challenges to clinicians, due to its …
COVID-19 and preexisting comorbidities: risks, synergies, and clinical outcomes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated
symptoms, named coronavirus disease 2019 (COVID-19), have rapidly spread worldwide …
symptoms, named coronavirus disease 2019 (COVID-19), have rapidly spread worldwide …