Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass,
strength, and physical function, severely affecting the quality of life (QoL) of the elderly …

The population of older individuals is increasing rapidly, but only a small fraction among
them is able to experiences a healthy life. Due to lack of physical exercise and oxidative …

Muscle wasting, also known as cachexia, is associated with many chronic diseases, which
worsens prognosis of primary illness leading to enhanced mortality. Molecular basis of this …

Muscular dystrophies are inherited myogenic disorders accompanied by progressive
skeletal muscle weakness and degeneration. Duchenne muscular dystrophy (DMD) is the …

Sirtuins (SIRTs) are seven nicotinamide adenine dinucleotide (NAD+)-dependent protein
deacetylases enzymes (SIRT1–7) that play an important role in maintaining cellular …

Sirtuins (SIRTs) were originally characterized by yeast Sir2 as a lifespan regulator that is
conserved in all three structural domains of bacteria, archaea and eukaryotes and belong to …

Abstract Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modify the gene
expression through histone deacetylation. SIRT1 plays a crucial role in regulating a wide …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III
nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases, whose …

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-
dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a …