[HTML][HTML] Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria
As the intestinal microbiota has become better appreciated as necessary for maintenance of
physiologic homeostasis and also as a modulator of disease processes, there has been a …
physiologic homeostasis and also as a modulator of disease processes, there has been a …
Dissecting the interplay between intestinal microbiota and host immunity in health and disease: lessons learned from germfree and gnotobiotic animal models
U Fiebiger, S Bereswill… - European Journal of …, 2016 - akjournals.com
This review elaborates the development of germfree and gnotobiotic animal models and
their application in the scientific field to unravel mechanisms underlying host—microbe …
their application in the scientific field to unravel mechanisms underlying host—microbe …
Baseline microbiota composition modulates antibiotic-mediated effects on the gut microbiota and host
A Lavelle, TW Hoffmann, HP Pham, P Langella… - Microbiome, 2019 - Springer
Background Normal mammalian development and homeostasis are dependent upon the gut
microbiota. Antibiotics, essential for the treatment and prophylaxis of bacterial infections, can …
microbiota. Antibiotics, essential for the treatment and prophylaxis of bacterial infections, can …
Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
DH Reikvam, A Erofeev, A Sandvik, V Grcic… - PloS one, 2011 - journals.plos.org
Background Inappropriate cross talk between mammals and their gut microbiota may trigger
intestinal inflammation and drive extra-intestinal immune-mediated diseases. Epithelial cells …
intestinal inflammation and drive extra-intestinal immune-mediated diseases. Epithelial cells …
Gnotobiotic Rodents: An In Vivo Model for the Study of Microbe–Microbe Interactions
R Martín, LG Bermúdez-Humarán… - Frontiers in …, 2016 - frontiersin.org
Germ-free rodents have no microorganisms living in or on them, allowing researchers to
specifically control an animal's microbiota through the direct inoculation of bacteria of …
specifically control an animal's microbiota through the direct inoculation of bacteria of …
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
Targeted manipulation of the gut flora is increasingly being recognized as a means to
improve human health. Yet, the temporal dynamics and intra-and interindividual …
improve human health. Yet, the temporal dynamics and intra-and interindividual …
The mouse gut microbiome revisited: from complex diversity to model ecosystems
Laboratory mice are the most commonly used animal model in translational medical
research. In recent years, the impact of the gut microbiota (ie communities of …
research. In recent years, the impact of the gut microbiota (ie communities of …
Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks
Objective Despite widespread use of antibiotics for the treatment of life-threatening
infections and for research on the role of commensal microbiota, our understanding of their …
infections and for research on the role of commensal microbiota, our understanding of their …
Manipulating the gut microbiota: methods and challenges
AC Ericsson, CL Franklin - ILAR journal, 2015 - academic.oup.com
Eukaryotic organisms are colonized by rich and dynamic communities of microbes, both
internally (eg, in the gastrointestinal and respiratory tracts) and externally (eg, on skin and …
internally (eg, in the gastrointestinal and respiratory tracts) and externally (eg, on skin and …
Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning
Background Human microbiota-associated (HMA) animal models relying on germ-free
recipient mice are being used to study the relationship between intestinal microbiota and …
recipient mice are being used to study the relationship between intestinal microbiota and …