Background: The minor T allele of rs2943641 near the gene encoding for insulin receptor
substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and …

OBJECTIVE Insulin receptor substrate 1 (IRS1) is central to insulin signaling pathways. This
study aimed to examine the association of IRS1 variants with insulin resistance (IR) and …

BACKGROUND AND AIMS: A recent genome-wide association study identified
rs2943641C> T, 500 kb from the insulin receptor substrate-1 gene (IRS1), as a type-2 …

Objective Published data concerning associations between IRS1 variants and type 2
diabetes and related traits have been inconsistent. We examined the relationship between …

Context: Obesity and insulin resistance are risk factors for cancer development. The IRS1
rs2943641 genetic variant has been widely associated with insulin resistance. Objective …

Type 2 diabetes mellitus (T2D) is a main public health problem in the Mexican population. It
is characterized by insulin resistance in peripheral tissues and a relative deficiency in the …

The relationship between the Gly972Arg polymorphism in the insulin receptor substrate-1
(IRS-1) gene and metabolic risk markers is not clear, possibly due to small sample sizes …

Objective Associations of IRS1 genetic variation with adiposity and metabolic profile in US
Hispanic/Latino individuals of diverse backgrounds were examined. Methods Previously …

Abstract Background: Insulin Receptor Substrate (IRS) molecules play a major role in insulin
signalling, and single nucleotide polymorphisms in the IRS-1 (rs1801278) and IRS-2 …

OBJECTIVE Genetic variants near IRS1 are associated with features of the metabolic
syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the …