[HTML][HTML] Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

HPA axis and aging in depression: systematic review and meta-analysis

MB Murri, C Pariante, V Mondelli, M Masotti… - …, 2014 - Elsevier
One of the most consistent findings in the biology of depression is an altered activity of the
hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never …

[HTML][HTML] Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

[HTML][HTML] The pathobiological basis of depression in Parkinson disease: challenges and outlooks

KA Jellinger - Journal of neural transmission, 2022 - Springer
Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric
disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive …

HPA axis function in mood disorders

S Watson, P Mackin - Psychiatry, 2006 - Elsevier
Mood disorders rank among the leading causes of disability worldwide, and are
characterized by biological, emotional, psychological and cognitive symptoms. The …

Neurobiology of depression in Parkinson's disease: Insights into epidemiology, molecular mechanisms and treatment strategies

MH Ahmad, MA Rizvi, M Ali, AC Mondal - Ageing research reviews, 2023 - Elsevier
Parkinson's disease (PD) is characterized mainly by motor dysfunctions due to the
progressive loss of dopaminergic neurons. However, PD patients experience a multitude of …

[HTML][HTML] Is AD a stress-related disorder? Focus on the HPA axis and its promising therapeutic targets

G Canet, C Hernandez, C Zussy… - Frontiers in aging …, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has important
health and economic impacts in the elderly. Despite a better understanding of the molecular …

Major depression, cognitive dysfunction and Alzheimer's disease: is there a link?

ASR Sierksma, DLA van den Hove… - European Journal of …, 2010 - Elsevier
Major depression (MD) is a severe mental disorder characterized by alterations in mood and
cognition, with disease severity correlating inversely with cognition scores. Neuropathology …

[HTML][HTML] Similarities between depression and neurodegenerative diseases: pathophysiology, challenges in diagnosis and treatment options

M Hussain, P Kumar, S Khan, DK Gordon, S Khan - Cureus, 2020 - ncbi.nlm.nih.gov
Depressive disorder and neurodegenerative diseases are two different clinical entities.
Depression is a common psychiatric disorder in the general population. However, when …