Balance dysfunction is closely associated with loss of vestibular hair cells (HCs). Gene
therapy shows promise when used to protect or regenerate vestibular HCs to preserve or …

Background Loss of vestibular hair cell is seen in various balance disorder diseases. There
have been some reports concerning gene delivery to the mouse vestibule in recent years …

The use of viral vectors for inner ear gene therapy is receiving increased attention for
treatment of genetic hearing disorders. Most animal studies to date have injected viral …

Objectives/Hypothesis Determine the optimal design characteristics of an adenoviral (Ad)
vector to deliver atoh1 and induce regeneration of vestibular hair cells. Study Design …

Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-
expression in the vestibular end organs. However, AAV has limited usefulness for delivering …

Loss of balance is often due to loss of vestibular hair cells. In mammals, regeneration of
functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory …

Therapies aimed at the protection and/or regeneration of inner ear hair cells are of great
interest, given the significant monetary and quality of life impact of balance disorders …

Adeno-associated virus (AAV) is a safe and effective vector for gene therapy for retinal
disorders. Gene therapy for hearing disorders is not as advanced, in part because gene …

Viral-mediated gene augmentation, silencing, or editing offers tremendous promise for the
treatment of inherited and acquired deafness. Inner-ear gene therapies often require a safe …

Viral delivery of exogenous coding sequences into the inner ear has the potential for
therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise …