Objective A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to
endothelial dysfunction and increased peripheral resistances during essential arterial …

Objective High vascular arginase activity and subsequent reduction in vascular nitric oxide
production were recently reported in animal models of hypertension. The present study …

Aims Growing evidence suggests that arginase misregulation plays a key role in the
pathophysiology of essential hypertension. In the present study, we investigated the …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …

Vascular tissues express arginase that metabolizes l-arginine to l-ornithine and urea and
thus reduces substrate availability for nitric oxide formation. Dahl salt-sensitive (Dahl-S) rats …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

One characteristic of hypertension is a decreased endothelium-dependent nitric oxide (NO)-
mediated vasodilation; however, the underlying mechanism is complex. In endothelial cells …

Reduced nitric oxide bioavailability contributes to increased cardiovascular disease risk in
patients with chronic kidney disease (CKD). Arginase has been implicated as a potential …

Objective This study investigated whether arginase contributes to endothelial dysfunction
and hypertension in obese rats. Methods Endothelial function and arginase expression were …