Hyperglycemia has been shown to modulate the immune response of peripheral immune
cells and organs, but the impact of hyperglycemia on neuroinflammation within the brain …

Background In cerebral ischemia, microglia have a dichotomous role in keeping the balance
between pro-and anti-inflammatory mediators to avoid deleterious chronic inflammation and …

Background High-fat feeding and hyperglycemia, key risk factors for the development of
metabolic syndrome (MetS), are emerging to associate with increased risk of developing …

Background Microglial activation-mediated neuroinflammation plays an important role in the
progression of neurodegenerative diseases. Inflammatory activation of microglial cells is …

Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation
involving microglial activation. However, the specific mechanism for microglial activation …

The relationship between neuroinflammation and mental disorders has been recognized
and investigated for over 30 years. Diseases of systemic or peripheral inflammation, such as …

Therapeutic interventions are greatly needed for age-related neurodegenerative diseases.
Astrocytes regulate many aspects of neuronal function including bioenergetics and synaptic …

Neuroinflammation is a common feature during the development of neurological disorders
and neurodegenerative diseases, where glial cells, such as microglia and astrocytes, play …

Microglia cells are the macrophage population within the central nervous system, which acts
as the first line of the immune defense. These cells present a high level of heterogeneity …

Methylglyoxal (MG) is considered a classical biomarker of diabetes mellitus and its
comorbidities. However, a role for this compound in exacerbated immune responses, such …