The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

As our understanding of the endocannabinoids improves, so does the awareness of their
complexity. During pathological states, the levels of these mediators in tissues change, and …

Knowledge of the endogenous cannabinoid system has expanded greatly during the past
years. After the discovery of the cannabinoid receptors, of their endogenous agonists and of …

The finding of endogenous ligands for cannabinoid receptors, the endocannabinoids,
opened a new era in cannabinoid research. It meant that the biological role of cannabinoid …

Endocannabinoid signalling is considered one of the most important modulatory systems in
a whole organism. Research has yielded great insight on the mechanisms that link …

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

The discovery of the endocannabinoid signalling system, that is, of cannabinoid receptors,
their endogenous ligands, known as endocannabinoids, and of endocannabinoid anabolic …