[PDF][PDF] Transcriptome Dysregulation in Hepatoblastoma: The Pivotal Role of Noncoding Rnas and Changes in Lipid Metabolism

MP Rivas, TFM Aguiar, EM de Andrade, SF Pires… - 2022 - researchgate.net
Hepatoblastoma, the most common liver tumor in children and exhibited the lowest
mutational burden among solid cancers, pointing to chromosomal and epigenetic changes …

First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways

TFM Aguiar, MP Rivas, EM de Andrade Silva… - Biochemical …, 2024 - Springer
Hepatoblastoma stands as the most prevalent liver cancer in the pediatric population.
Characterized by a low mutational burden, chromosomal and epigenetic alterations are key …

Whole-genome sequencing and RNA sequencing analysis reveals novel risk genes and differential expression patterns in hepatoblastoma

W Wang, N Zhang, L Chen, X Zhao, Y Shan, F Yang… - Gene, 2024 - Elsevier
Hepatoblastoma (HB) is an uncommon malignant liver cancer primarily affecting infants and
children, characterized by the presence of tissue that resembling fetal hepatocytes, mature …

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

J Carrillo-Reixach, L Torrens, M Simon-Coma… - Journal of …, 2020 - Elsevier
Background & Aims Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the
predominant pediatric liver cancer, with limited therapeutic options for patients with …

Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets

M Sekiguchi, M Seki, T Kawai, K Yoshida… - NPJ precision …, 2020 - nature.com
Although hepatoblastoma is the most common pediatric liver cancer, its genetic
heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a …

[HTML][HTML] Identification of differentially expressed genes, lncRNAs and miRNAs which are associated with tumor malignant phenotypes in hepatoblastoma patients

S Liu, F Xie, X Xiang, S Liu, S Dong, K Qu, T Lin - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hepatoblastoma (HB) is one of the most common hepatic malignancies in the pediatric
population. HB are composed of a variety of tumors, which derived from different origins and …

[HTML][HTML] Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict hepatoblastoma survival

A Pire, TZ Hirsch, G Morcrette, S Imbeaud… - European Journal of …, 2024 - Elsevier
Background Hepatoblastoma is the most frequent pediatric liver cancer. The current
treatments lead to 80% of survival rate at 5 years. In this study, we evaluated the clinical …

The genomic landscape of hepatoblastoma and their progenies with HCC-like features

M Eichenmüller, F Trippel, M Kreuder, A Beck… - Journal of …, 2014 - Elsevier
Background & Aims Hepatoblastoma (HB) is the most common childhood liver cancer and
occasionally presents with histological and clinical features reminiscent of hepatocellular …

[PDF][PDF] Bridging molecular basis, prognosis, and treatment of pediatric liver tumors

C Armengol, S Cairo, R Kappler - Hepatoma Res, 2021 - f.oaes.cc
A deeper understanding of the genetic and molecular basis of hepatoblastoma (HB) has
fueled the hope to help in identifying genes and signaling pathways that are amenable to …

The role of microRNAs in hepatoblastoma tumors

I Cristóbal, M Sanz-Álvarez, M Luque, C Caramés… - Cancers, 2019 - mdpi.com
Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is
still known about the molecular mechanisms that govern the development of this disease …