Recent developments on the synthesis of biologically active glycohybrids

VK Mishra, A Khanna, G Tiwari, R Tyagi, R Sagar - Bioorganic Chemistry, 2024 - Elsevier
The exploration of hybridization emerges as a potent tool in advancing drug discovery
research, with a significant emphasis on carbohydrate-containing hybrid scaffolds. Evidence …

Recent progress in the synthesis of natural product inspired bioactive glycohybrids

K Singh, S Sharma, R Tyagi, R Sagar - Carbohydrate Research, 2023 - Elsevier
Carbohydrates are a basic structural component that are indispensable to all cellular
processes. In addition to being employed as chiral starting materials in the synthesis of a …

[HTML][HTML] Recent advances in the synthesis of bioactive glycohybrids via click-chemistry

K Singh, R Tyagi, VK Mishra, G Tiwari, R Sagar - SynOpen, 2023 - thieme-connect.com
Carbohydrates, traditionally known for their energy-providing role, have gained significant
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …

Carbohydrates in diversity-oriented synthesis: challenges and opportunities

E Lenci, G Menchi, A Trabocchi - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
Over the last decade, Diversity-Oriented Synthesis (DOS) has become a new paradigm for
developing large collections of structurally diverse small molecules as probes to investigate …

Development of Diverse Range of Biologically Relevant Carbohydrate‐Containing Molecules: Twenty Years of Our Journey

VK Tiwari - The Chemical Record, 2021 - Wiley Online Library
There is an increasing demand for significant amount of carbohydrate‐containing molecules
owing to their complete chemical, biological, and pharmacological investigations to better …

Recent trends and challenges on carbohydrate-based molecular scaffolding: General consideration toward impact of carbohydrates in drug discovery and …

N Mishra, VK Tiwari, RR Schmidt - Carbohydrates in Drug Discovery and …, 2020 - Elsevier
Carbohydrates, the structural building blocks of genetic materials and vital source of energy,
are integral part of the living cells as they play important roles in biological system …

Carbohydrate-based therapeutics: a frontier in drug discovery and development

S Mishra, K Upadhaya, KB Mishra, AK Shukla… - Studies in Natural …, 2016 - Elsevier
Carbohydrates, one of the most abundant classes of biomolecules, are the structural
building blocks of genetic materials and vital source of energy. They are integral part of the …

Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry

L Cipolla, B La Ferla, C Airoldi, C Zona… - Future medicinal …, 2010 - Taylor & Francis
Several glycoprocessing enzymes and glycoreceptors have been recognized as important
targets for therapeutic intervention. This concept has inspired the development of important …

Glycohybrid molecules in medicinal chemistry: Present status and future prospective

P Kumari, C Narayana, G Tiwari, R Sagar - Carbohydrates in Drug …, 2020 - Elsevier
Hybrid molecules combine two distinct biologically relevant molecules that act at different
biological targets with new mechanism are becoming molecules for interest among …

Recent developments in solid-and solution-phase methods for generating carbohydrate libraries.

MJ Sofia, DJ Silva - Current Opinion in Drug Discovery & …, 1999 - europepmc.org
Carbohydrates and glycoconjugates have attracted a great deal of attention in recent years
because of the key roles they play in biological processes. The development of …