Carbohydrate diversity is foundational in the molecular literacy that regulates cellular
function and communication. Consequently, delineating and leveraging this structure …

The usefulness of 18F-labelled carbohydrates, especially 2-deoxy-2-[18F] fluoro-d-glucose,
to study pathophysiological processes in man non-invasively using positron-emission …

In the field of 18F-chemistry for the development of radiopharmaceuticals for positron
emission tomography (PET), various labeling strategies by the use of prosthetic groups have …

The high rate of glucose uptake to fuel the bioenergetic and anabolic demands of
proliferating cancer cells is well recognized and is exploited with 18F-2-fluoro-2-deoxy-d …

At the time when the highly efficient [18F] FDG synthesis was discovered by the use of the
effective precursor 1, 3, 4, 6‐tetra‐O‐acetyl‐2‐O‐trifluoromethanesulfonyl‐β‐D …

Positron emission tomography (PET) is an important diagnostic tool in modern medicine,[1]
where it is routinely used to locate and assess abnormalities in oncology,[2] neurology,[3] …

The abnormality in the glycosylation of surface proteins is critical for the growth and
metastasis of tumors and their capacity for immunosuppression and drug resistance. This …

FDG-based imaging with positron emission tomography (PET) has been widely used in the
detection of cancer, but has not reached its full potential. In breast cancer, the …

This paper provides a historical perspective and update of the methods of preparation and
properties at 2-deoxy-/sup 18/F-fluoro-d-glucose (/sup 18/FDG) and discusses some current …

Solid tumors are hypoxic with altered metabolism, resulting in secretion of acids into the
extracellular matrix and lower relative pH, a feature associated with local invasion and …