Pathophysiology of preeclampsia and L-arginine/L-citrulline supplementation as a potential strategy to improve birth outcomes

T Ortiz-Cerda, C Mosso, A Alcudia… - Advances in Maternal …, 2023 - Springer
In preeclampsia, the shallow invasion of cytotrophoblast cells to uterine spiral arteries,
leading to a reduction in placental blood flow, is associated with an imbalance of …

L-Arginine supplementation in pregnancy: a systematic review of maternal and fetal outcomes

D Menichini, L Feliciello, I Neri… - The Journal of Maternal …, 2023 - Taylor & Francis
Background/aim of the study L-Arginine (L-Arg)/Nitric Oxide (NO) system is involved in the
pathophysiology of relevant Obstetric conditions. This review aims at summarizing the …

l-Citrulline supplementation during pregnancy improves perinatal and postpartum maternal vascular function in a mouse model of preeclampsia

M Gemmel, EF Sutton, J Brands… - American Journal …, 2021 - journals.physiology.org
Preeclampsia is a spontaneously occurring pregnancy complication diagnosed by new-
onset hypertension and end-organ dysfunction with or without proteinuria. This pregnancy …

[HTML][HTML] Perspective: L-arginine and L-citrulline supplementation in pregnancy: a potential strategy to improve birth outcomes in low-resource settings

AM Weckman, CR McDonald, JAB Baxter… - Advances in …, 2019 - Elsevier
The available data support the hypothesis that L-arginine or L-citrulline supplementation
would be suitable for implementation in resource-constrained settings and will enhance …

[HTML][HTML] Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia

K Matsubara, T Higaki, Y Matsubara… - International journal of …, 2015 - mdpi.com
Preeclampsia (PE) is characterized by disturbed extravillous trophoblast migration toward
uterine spiral arteries leading to increased uteroplacental vascular resistance and by …

Radicals, oxidative/nitrosative stress and preeclampsia

S Taysi, AS Tascan, MG Ugur… - Mini reviews in medicinal …, 2019 - ingentaconnect.com
Preeclampsia (PE) has a profound effect in increasing both maternal and fetal morbidity and
mortality especially in third World. Disturbances of extravillous trophoblast migration toward …

The role of I-arginine in human pregnancy

M Castillo-Castrejon, A Migoya-Graue… - Agro Food Industry Hi …, 2011 - hero.epa.gov
L-arginine is a semi-essential amino acid dependent upon the functional circumstances.
Pregnancy is a condition in which demands for L-arginine are increased because of the …

The role of nitric oxide, ADMA, and homocysteine in the etiopathogenesis of preeclampsia

W Dymara-Konopka, M Laskowska - International Journal of Molecular …, 2019 - mdpi.com
Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound
aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause …

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction–implications as a preeclampsia …

NJ Hannan, FC Brownfoot, P Cannon, M Deo… - Scientific reports, 2017 - nature.com
Preeclampsia is a disease of pregnancy associated with placental oxidative stress,
inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin …

l-Arginine Infusion Reduces Blood Pressure in Preeclamptic Women Through Nitric Oxide Release

F Facchinetti, M Longo, F Piccinini, I Neri… - The Journal of the Society …, 1999 - Springer
Objective This study investigates the biochemical and cardiovascular effects of L-arginine
administration in normotensive pregnant women and women with preeclampsia. Methods …