Systems pharmacology in drug discovery and therapeutic insight for herbal medicines
Abstract Systems pharmacology is an emerging field that integrates systems biology and
pharmacology to advance the process of drug discovery, development and the …
pharmacology to advance the process of drug discovery, development and the …
[HTML][HTML] Systems pharmacology approaches in herbal medicine research: a brief review
Herbal medicine, a multi-component treatment, has been extensively practiced for treating
various symptoms and diseases. However, its molecular mechanism of action on the human …
various symptoms and diseases. However, its molecular mechanism of action on the human …
Network analyses in systems pharmacology
SI Berger, R Iyengar - Bioinformatics, 2009 - academic.oup.com
Abstract Systems pharmacology is an emerging area of pharmacology which utilizes
network analysis of drug action as one of its approaches. By considering drug actions and …
network analysis of drug action as one of its approaches. By considering drug actions and …
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
Background Modern medicine often clashes with traditional medicine such as Chinese
herbal medicine because of the little understanding of the underlying mechanisms of action …
herbal medicine because of the little understanding of the underlying mechanisms of action …
Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice
H Liu, J Wang, W Zhou, Y Wang, L Yang - Journal of ethnopharmacology, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Licorice, one of the oldest and most popular
herbal medicines in the world, has been widely used in traditional Chinese medicine as a …
herbal medicines in the world, has been widely used in traditional Chinese medicine as a …
Network pharmacology-based approaches capture essence of Chinese herbal medicines
Y Zhang, X Mao, Q Guo, N Lin, S Li - Chinese Herbal Medicines, 2016 - Elsevier
Abstract Traditional Chinese Medicine (TCM), a crucial component of the current medical
system, has been extensively used in clinical practice due to its valuable therapeutic …
system, has been extensively used in clinical practice due to its valuable therapeutic …
Network-based drug discovery by integrating systems biology and computational technologies
Network-based intervention has been a trend of curing systemic diseases, but it relies on
regimen optimization and valid multi-target actions of the drugs. The complex multi …
regimen optimization and valid multi-target actions of the drugs. The complex multi …
Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products
M Kibble, N Saarinen, J Tang, K Wennerberg… - Natural product …, 2015 - pubs.rsc.org
Covering: 2011 to 2014 It is widely accepted that drug discovery often requires a systems-
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …
From single-to multi-omics: future research trends in medicinal plants
L Yang, Y Yang, L Huang, X Cui… - Briefings in bioinformatics, 2023 - academic.oup.com
Medicinal plants are the main source of natural metabolites with specialised
pharmacological activities and have been widely examined by plant researchers. Numerous …
pharmacological activities and have been widely examined by plant researchers. Numerous …
Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases
Ethnopharmacological relevance Multi-target therapeutics is a promising paradigm for drug
discovery which is expected to produce greater levels of efficacy with fewer adverse effects …
discovery which is expected to produce greater levels of efficacy with fewer adverse effects …