Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …

The societal impact of obesity, diabetes, and other metabolic disorders continues to rise
despite increasing evidence of their negative long-term consequences on health span …

Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …

Highlights•Traditional calorie restriction robustly improves markers of aging in
humans.•Novel dietary strategies may be substitutes for calorie restriction.•Intermittent …

Background Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake,
increases life span in many species. The implications for humans can be clarified by …

Calorie restriction (CR) extends life span and retards age-related chronic diseases in a
variety of species, including rats, mice, fish, flies, worms, and yeast. The mechanism or …

Eur J Clin Invest 2010; 40 (5): 440–450 Abstract Background Calorie Restriction (CR)
research has expanded rapidly over the past few decades and CR remains the most highly …

Epidemiological and experimental data indicate that diet plays a central role in the
pathogenesis of many age-associated chronic diseases, and in the biology of aging itself …

Calorie Restriction (CR) without malnutrition slows aging and increases average and
maximal lifespan in simple model organisms and rodents. In rhesus monkeys long-term CR …

Calorie restriction (CR) is the most potent, non-pharmacological intervention to support
metabolic health. The effects of calorie restriction exceed weight loss. Consistent throughout …