The tumor-draining lymph nodes (TDLNs) are the primary sites of the development of anti-
tumor immunity. Primary tumor irradiation promotes 'radio-vaccination'by enhancing the …

Lymph nodes that lie immediately downstream of tumors [tumor‐draining lymph nodes
(TDLNs)] undergo profound alterations due to the presence of the upstream tumor. The …

We have previously reported that local tumor irradiation, without inducing cell death, can
augment the therapeutic efficacy of intratumoral (IT) dendritic cell (DC) vaccination. This …

Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …

Metastasis to lymph nodes (LNs) is a common feature of disease progression in most solid
organ malignancies. Consequently, LN biopsy and lymphadenectomy are common clinical …

Background Currently, due to synergy enhancement of anti‐tumor effects and potent
stimulation of abscopal effects, combination therapy with irradiation and programmed cell …

This review examines the crucial role of regional lymph nodes (RLN) in defense against
tumor progression. RLN are one of the first major components of the immune system to …

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-
tumor T-cell immune response. However, cancer-derived immune suppressive factors …

Radiotherapy is an important therapeutic option for the treatment of cancer. Growing
evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy …

BACKGROUND Although, to the authors' knowledge, no prospective randomized clinical
trial has demonstrated improvement in survival following the radical dissection of lymph …