Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression

PS Chong, CH Poon, J Roy, KC Tsui, SY Lew… - Chinese Medicine, 2021 - Springer
Background Depression is a severe neuropsychiatric disorder that affects more than 264
million people worldwide. The efficacy of conventional antidepressants are barely adequate …

Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain

S Ryu, HG Kim, JY Kim, SY Kim, KO Cho - Journal of medicinal food, 2018 - liebertpub.com
Versatile biological activities of Hericium erinaceus (HE) have been reported in many brain
diseases. However, roles of HE in major psychiatric disorders such as depression and …

Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

CH Chiu, CC Chyau, CC Chen, LY Lee… - International journal of …, 2018 - mdpi.com
Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium
enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) …

Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells

SY Lew, SH Lim, LW Lim, KH Wong - BMC complementary medicine and …, 2020 - Springer
Background Hericium erinaceus is a culinary and medicinal mushroom in Traditional
Chinese Medicines. It has numerous pharmacological effects including immunomodulatory …

[HTML][HTML] Therapeutic potential of Hericium erinaceus for depressive disorder

PS Chong, ML Fung, KH Wong, LW Lim - International journal of …, 2020 - mdpi.com
Depression is a common and severe neuropsychiatric disorder that is one of the leading
causes of global disease burden. Although various anti-depressants are currently available …

Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

M Nagano, K Shimizu, R Kondo, C Hayashi… - Biomedical …, 2010 - jstage.jst.go.jp
Hericium erinaceus, a well known edible mashroom, has numerous biological activities.
Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth …

Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway

CC Zhang, CY Cao, M Kubo, K Harada, XT Yan… - International journal of …, 2017 - mdpi.com
Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to
improve memory. In this work, we investigated the neuroprotective and neuritogenic effects …

Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells …

CW Phan, GS Lee, SL Hong, YT Wong, R Brkljača… - Food & Function, 2014 - pubs.rsc.org
Hericium erinaceus (Bull.: Fr.) Pers. is an edible and medicinal mushroom used traditionally
to improve memory. In this study, we investigated the neuritogenic effects of hericenones …

The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 …

TT Tzeng, CC Chen, CC Chen, HJ Tsay… - International journal of …, 2018 - mdpi.com
Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial
medicines. Recently, it has become a candidate in causing positive brain health-related …

[HTML][HTML] Naringin mediates adult hippocampal neurogenesis for antidepression via activating CREB signaling

C Gao, M Wu, Q Du, J Deng, J Shen - Frontiers in cell and …, 2022 - frontiersin.org
Brain-derived neurotrophic factor/tropomycin receptor kinase B/cAMP response element-
binding protein (BDNF/TrkB/CREB) signaling pathway becomes a critical therapeutic target …