Selective atonal gene delivery improves balance function in a mouse model of vestibular disease
C Schlecker, M Praetorius, DE Brough, RG Presler… - Gene therapy, 2011 - nature.com
Loss of balance is often due to loss of vestibular hair cells. In mammals, regeneration of
functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory …
functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory …
Repair of the vestibular system via adenovector delivery of Atoh1: a potential treatment for balance disorders
K Baker, DE Brough, H Staecker - Gene Therapy of Cochlear Deafness, 2009 - karger.com
Loss of auditory and vestibular hair cells is a common cause of hearing loss and balance
disorders. A variety of strategies have been proposed to restore function to damaged inner …
disorders. A variety of strategies have been proposed to restore function to damaged inner …
Optimizing atoh1‐induced vestibular hair cell regeneration
H Staecker, C Schlecker, S Kraft… - The …, 2014 - Wiley Online Library
Objectives/Hypothesis Determine the optimal design characteristics of an adenoviral (Ad)
vector to deliver atoh1 and induce regeneration of vestibular hair cells. Study Design …
vector to deliver atoh1 and induce regeneration of vestibular hair cells. Study Design …
Adeno-associated virus-mediated gene transfer targeting normal and traumatized mouse utricle
Balance dysfunction is closely associated with loss of vestibular hair cells (HCs). Gene
therapy shows promise when used to protect or regenerate vestibular HCs to preserve or …
therapy shows promise when used to protect or regenerate vestibular HCs to preserve or …
Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer
H Staecker, M Praetorius, K Baker… - Otology & …, 2007 - journals.lww.com
Background: Loss of peripheral vestibular function is associated with disease processes
such as vestibular neuronitis, aminoglycoside ototoxicity, and aging. Loss of vestibular hair …
such as vestibular neuronitis, aminoglycoside ototoxicity, and aging. Loss of vestibular hair …
Gene transfer targeting mouse vestibule using adenovirus and adeno-associated virus vectors
H Okada, T Iizuka, H Mochizuki, T Nihira… - Otology & …, 2012 - journals.lww.com
Background Loss of vestibular hair cell is seen in various balance disorder diseases. There
have been some reports concerning gene delivery to the mouse vestibule in recent years …
have been some reports concerning gene delivery to the mouse vestibule in recent years …
Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research
H Staecker, M Praetorius, DE Brough - Hearing research, 2011 - Elsevier
Despite the significant impact of hearing and balance disorders on the general population
there are currently no dedicated pharmaceuticals that target the inner ear. Advances in …
there are currently no dedicated pharmaceuticals that target the inner ear. Advances in …
Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate
Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate
hearing and balance disorders. We previously established the benefits of Anc80L65 in …
hearing and balance disorders. We previously established the benefits of Anc80L65 in …
Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse
M Praetorius, K Baker, DE Brough, P Plinkert… - Hearing research, 2007 - Elsevier
Recent studies have demonstrated that delivery of genes to the inner ear can achieve a
variety of effects ranging from support of auditory neuron survival to protection and …
variety of effects ranging from support of auditory neuron survival to protection and …
Gene therapy in the inner ear using adenovirus vectors
J Husseman, Y Raphael - Gene Therapy of Cochlear Deafness, 2009 - karger.com
Therapies for the protection and regeneration of auditory hair cells are of great interest given
the significant monetary and lifestyle impact of hearing loss. The past decade has seen …
the significant monetary and lifestyle impact of hearing loss. The past decade has seen …