Objective: Thickened atherosclerotic plaques are prone to be hypoxic because of poor
perfusion. In this study, we tested (a) whether reactive oxygen species (ROS) and c-Src play …

Significance: The role of reactive oxygen species (ROS) in angiotensin II (AngII) induced
endothelial dysfunction, cardiovascular and renal remodeling, inflammation, and fibrosis has …

Reactive oxygen species (ROS) are key mediators in signal transduction of angiotensin II
(Ang II). However, roles of vascular mitochondria, a major intracellular ROS source, in …

Acute hypoxia causes pulmonary vasoconstriction and coronary vasodilation. The divergent
effects of hypoxia on pulmonary and coronary vascular smooth muscle cells suggest that the …

Once thought of as toxic by-products of cellular metabolism, reactive oxygen species (ROS)
have been implicated in a large variety of cell-signaling processes. Several enzymatic …

Mitochondria are traditionally known as the energy generating centers of cells. Electron flux
through the mitochondrial respiratory chain, an organized sequence of complex enzymes …

Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor for responses to low oxygen.
Different nonhypoxic stimuli, including hormones and growth factors, are also important HIF …

Endothelial cells increase their secretion of the cytokine interleukin-6 (IL-6) during hypoxia,
which then acts in an autocrine fashion to increase the permeability of cell monolayers …

Hypoxia and hypoxia–reperfusion (HR) play important roles in human pathophysiology
because they occur in clinical conditions such as circulatory shock, myocardial ischemia …

Objectives: We sought to examine the presence of hypoxia in human carotid atherosclerosis
and its association with hypoxia-inducible transcription factor (HIF) and intraplaque …