Knee pain, the most common cause of musculoskeletal pain (MSK), constitutes a severe
public health burden. Its neurobiological causes, however, remain poorly understood …

Knee osteoarthritis (KOA) is the most common cause of musculoskeletal pain (MSK),
constituting a major public health burden. Sleep is among the multiple factors contributing to …

Chronic pain is driven by factors across the biopsychosocial spectrum. Previously, we
demonstrated that magnetic resonance images (MRI)-based brain-predicted age differences …

We have previously reported that older adults with chronic musculoskeletal pain had
significantly older-appearing brains compared to older controls in a small, mainly Non …

Chronic pain has been associated with changes in pain-related brain structure and function,
including advanced brain aging. Non-pharmacological pain management is central to …

Knee osteoarthritis is a leading cause of chronic pain in adults (1, 2). Yet its impact varies (3,
4), and may be influenced by changes in the central nervous system (5, 6), similar to …

Introduction Musculoskeletal pain is prevalent in older adults representing the leading cause
of disability in this population. Similarly, nearly half of older adults complain of difficulty …

Study Objectives: The objective of this study was to examine independent and interactive
associations between self-reported sleep (sleep efficiency and total sleep time [TST]) and …

Emergent work suggests that sleep is a robust biobehavioral predictor of pain; however, it
remains unclear how sleep is prospectively linked to pain on a day-to-day basis among …

Aging is associated with poor sleep quality, and greater chronic pain prevalence with age-
related changes in brain function as potential underlying mechanisms. The following cross …