The inner ears of adult humans and other mammals possess a limited capacity for
regenerating sensory hair cells, which can lead to permanent auditory and vestibular …

The increase in life expectancy is accompanied by the growing burden of chronic diseases.
Hearing loss is perhaps the most prevalent of all chronic diseases. In addition to age-related …

Because of their limited regenerative potential, cochlear hair cell loss is one of the major
causes of permanent hearing loss in mammals. However, recent studies have shown that …

Aim: Mouse mesenchymal stem cells (MSCs) can generate sensory neurons and produce
inner ear hair cell-like cells. An equivalent source from humans is highly desirable, given …

Background Hearing loss affects 25% of the population at ages 60–69 years. Loss of the
hair cells of the inner ear commonly underlies deafness and once lost this cell type cannot …

The inner ear contains many types of cell, including sensory hair cells and neurons. If these
cells are damaged, they do not regenerate. Inner ear disorders have various etiologies …

Background Hair cells are important for maintaining our sense of hearing and balance.
However, they are difficult to regenerate in mammals once they are lost. Clarification of the …

The inner ear of mammals uses neurosensory cells derived from the embryonic ear for
mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts …

The ear develops through the transformation of embryonic ectoderm into the labyrinth and,
through a stepwise molecular restriction of cell fate options, into cells neurosensory cells …

Many elderly people worldwide lose the neurosensory part of their ear and turn deaf.
Cochlear implants to restore some hearing after neurosensory hearing loss are, at present …