Background Herpes simplex virus type-1 (HSV-1) is the primary cause of facial lesions
(mouth, lips, and eyes) in humans. The widespread use of acyclovir and nucleoside …

Background: Several commercial drugs utilized in the treatment of HSV containing
pyrimidine moiety. Because of the ineffectiveness of virus drugs due to the resistance of the …

Abstract a new series of 6-substituted N1-and N2-β-D-ribofuranosyl-pyrazolo [3, 4-d]
pyridazin-7 (6H)-one derivatives (8a-g, 9b-d and 9f-g) has been prepared in the aim to …

In this work, a new series of arysulfonylhydrazine-1H-1, 2, 3-triazole derivatives were
synthesized, and their ability to inhibit the in vitro replication of HSV-1 was evaluated …

A pyrazolo [3, 4-b] pyridine-5-carbonitrile derivative was diazotized to give the
corresponding diazonium salt, which was used as a good synthon to synthesize pyrido [2 …

Herpesviruses are a significant source of human disease; amongst these herpes simplex
virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently …

1-(3-Amino-6-methyl-4-pyridin-3-yl-1H-pyrazolo [3, 4-b] pyridin-5-yl) ethanone (3) was
obtained in very pure state and used as a good starting material for the present study. It …

In a one pot procedure, 18 compounds of 7-(substituted phenyl)-2-substituted-6, 7-dihydro-
4H-[1, 2, 4] triazolo [1, 5-a] pyrimidin-5-one derivatives (16–33) have been synthesized. 3 (5) …

Several options for treating Herpes Simplex Virus type 1 and type 2 are available. However,
non-specific inhibition and drug resistance warrants the discovery of new anti-herpetic …

As part of our search for new compounds having antiviral effects, the prepared 2-
aminonaphthalimide series was examined for its activity against the herpes simplex viruses …